Conclusion.
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The form of “detoxification” described above has yet to be proved effective for treatment of allergy, IEI, drug addiction, or any other illness. The ability of the procedure to remove chemicals from fat has not been proved. The theory of immunotoxicity as a cause of allergic disease is contrary to accumulated scientific experimentation. The potential dangers of this program have not yet been adequately evaluated.

Claims of therapeutic properties of human urine go back to ancient times. In the early 1930s several medical publications claimed that a specific substance, called “proteose,” is present during allergic disease. Injections of extracts of this substance were recommended for treatment of allergy, and there were reports of successes in many other diseases. Other reports could not reproduce these findings. The practice subsided after several years, but it has resurfaced recently.
Method.
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Several chemical extraction procedures have been recommended for obtaining “proteose” from the urine. The extracted protein is suspended in a buffered solution and then injected for intradermal testing and for subcutaneous therapeutic injections.
Theory.

Proponents of this form of treatment believe that urinary “proteose” contains the allergen specific for that particular individual. They believe that it is a superior source of allergen for therapy, having gone through some type of unspecified processing by the body.
Studies.

The published reports consist of uncontrolled anecdotal histories of apparently successful treatment of a variety of allergic conditions, including asthma, rhinitis, anaphylaxis, urticaria, angioedema, and serum sickness. Other reports have failed to prove efficacy. No studies using proper controls have been performed.
Safety.
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There have been no studies addressing the question of long-term safety. This is critical because small quantities of glomerular basement membrane antigens are found in normal urine. It is not unreasonable that alteration by chemical treatment during the extraction process could lead to the production of altered renal proteins that might induce autoantibodies.
Conclusion.

The practice of injecting an extract of the patient’s own urine for diagnosis or treatment of allergy is clearly unacceptable and must be discouraged. It is not based on a rational theory, and there have been no scientific investigations of efficacy or safety. The potential for induction of autoimmune nephritis is a clear danger that should preclude consideration of this procedure in humans, even on an experimental basis

In recent years numerous “detoxification centers” have been established for treatment of drug addiction. More recently chemical detoxification has been recommended by a small group of practitioners to remove undesirable chemicals from patients believed to have IEI, based on the concept that the sensitivity is caused by toxic effects of low-level synthetic chemicals in the body.
The Procedure.
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Treatment consists of several steps. Aerobic physical exercise is performed for 20 to 30 minutes, followed immediately by forced sweating in a sauna at 140° to 180° F for 2½ to 5 hours and then physical exercise, a cooling shower, and additional exercise. Niacin is then given in increasing doses to produce a flush. Water and salts of sodium, potassium, calcium, magnesium, and other minerals are prescribed to correct for water and salt depletion from sweating. Polyunsaturated oils (a mixture of soybean, walnut, peanut, and safflower oils, which are said to be essential) are consumed orally. A planned schedule of balanced meals and adequate sleep is recommended, along with avoidance of medications and alcohol.

The routine described above is repeated daily, usually for 30 days.
Theory.

The enforced program of exercise and sweating with niacin-induced cutaneous vasodilation is believed to mobilize fat-soluble “toxic chemicals,” presumably into the circulation, where they are excreted. The oil ingestion is to prevent reabsorption of chemicals through the normal enterohepatic recirculation. The “essential oils” are believed to allow toxic substances mobilized into the gut to be excreted from the colon, but some toxic material is believed to be excreted also through sweat.
Studies of Effectiveness.
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All reports up to now by proponents of this detoxification procedure are anecdotal. Results are measured by the patient’s self-report of symptomatic improvement. Placebo effect, proper diet, elimination of unnecessary medications, exercise, and adequate sleep therefore have not been ruled out as the reason for subjective improvement.

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